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Power-actuated fasteners (PAFs) are an industry standard for the attachment of cold-formed steel (CFS) framing members, usually track to concrete, concrete masonry unit (CMU) or steel structural elements. “Power-actuated” is the broad category used to refer to fasteners which are driven directly through the CFS and into the substrate using a powder, gas, compressed air or electromechanically- driven tool. Efficient installation of framing systems is greatly enhanced by the use of PAFs. For CFS-to- steel applications, AISI S100, North American Specification for the Design of Cold-Formed Steel Structural Members addresses all relevant limit states with equations and safety/resistance factors. For CFS-to-concrete, limited guidance is provided but not all limit states are covered. This Technical Note will provide guidance on design, installation and good detailing practices based on AISI S100.