The design provisions for screw connections contained in the North American Specification for the Design of Cold-Formed Steel Structural Members, AISI S100-07 with 2010 Addendum, contains specific limit states equations that pertain to the design strength of the connecting elements, i.e. sheets. In addition to sheet related design limit states, AISI S100 also provides design provisions for the screw when subjected to either pure shear or pure tension. However, the screw design provisions require that the screw capacity be defined by tests. In the absence of test data, the design engineer is at a loss for evaluating the strength of the screw. This Tech Note provides design guidance for the evaluation of the screw when subjected to pure shear, pure tension and combined shear and tension.